blood pressure — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T5471	GUANABENZ		Adrenergic Receptor
	GUANABENZ is a Central alpha-2 Adrenergic Agonist. The mechanism of action of guanabenz is as an Adrenergic alpha2-Agonist.		Adrenergic Receptor
T13482	2'-O-Methyladenosine		Endogenous Metabolite
	2'-O-Methyladenosine, a methylated adenine residue is found in the urine of normals and adenosine deaminase deficient patients. It shows unique hypotensive activities.		Endogenous Metabolite
T6792	BQ-123	BQ123	Endothelin Receptor
	BQ-123 is a selective endothelin A receptor (ETA) antagonist with IC50 of 7.3 nM. Phase 2.		Endothelin Receptor
T21957	Guanabenz hydrochloride	NE56490	Adrenergic Receptor
	Guanabenz hydrochloride (NE56490) is an orally active α2-adrenoceptor agonist with hypotensive effects.		Adrenergic Receptor
T7686	Ramiprilat		RAAS
	Ramiprilat is an angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity.		RAAS
T0022	Taurine	2-Aminoethanesulfonic acid	LDL , Endogenous Metabolite , Autophagy
	Taurine (2-Aminoethanesulfonic acid), an organic acid, is distributed in various animal tissues.		LDL , Endogenous Metabolite , Autophagy
T22368	Metyrosine	α-Methyltyrosine	COX
	Metyrosine (α-Methyltyrosine) is an antihypertensive drug and could be used as a tyrosine hydroxylase inhibitor.Metyrosine significantly inhibits high COX-2 activity. Metyrosine is a very effective agent for blood pressu...		COX
T1498	Indapamide	Veroxil,Noranat,Tertensif	Potassium Channel
	Indapamide (Noranat) is a non-thiazide sulphonamide diuretic compound, generally used in the treatment of hypertension, as well as decompensated cardiac failure.		Potassium Channel
T22398	Phenidone	1-phenyl-3-pyrazolidinone	Lipoxygenase , COX
	Phenidone (1-phenyl-3-pyrazolidinone) is a dual inhibitor of cyclooxygenases and lipoxygenases that ameliorates rat paralysis in experimental autoimmune encephalomyelitis by suppressing its target enzymes[1]. The lipoxyg...		Lipoxygenase , COX
T6581	Methyclothiazide	Duretic,Enduron,Aquatensen	Others , Carbonic Anhydrase
	Methyclothiazide (Aquatensen) is a substituted benzothiadiazide, used to treat high blood pressure and fluid retention caused by various conditions including heart disease.		Others , Carbonic Anhydrase
T4277	Osilodrostat	LCI699	Glucocorticoid Receptor , Others , Hydroxylase
	Osilodrostat (LCI699) (LCI699) is an effective inhibitor of human 11β-hydroxylase (IC50: 2.5 nM) and aldosterone synthase (IC50: 0.7 nM).		Glucocorticoid Receptor , Others , Hydroxylase
T0145	Felodipine	CGH-869	Calcium Channel , Autophagy
	Felodipine (CGH-869) is a longlasting 1, 4-dihydropyridine calcium channel repressor.		Calcium Channel , Autophagy
T6716	Valsartan	Diovan,Tareg,CGP 48933	RAAS
	Valsartan (CGP 48933) is a tetrazole derivative and angiotensin II type 1 receptor blocker that is used to treat hypertension.		RAAS
T4488	GSK-25	GSK25	ROCK , S6 Kinase , mTOR
	GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K (RSK1 IC50 of 398 nM, p70S6K IC50 of 1000nM), and a dramatically improved P450 profile (>2.2 uM at all isozymes tested).		ROCK , S6 Kinase , mTOR
T21454	Nicardipine	Cardene,Dagan,Antagonil,Flusemide	Calcium Channel
	Nicardipine (Cardene), a calcium channel blockers belonging to the dihydropyridine class, is a drug used to treat angina and high blood pressure.		Calcium Channel
T28482	Firibastat	QGC 001,QGC-001,RB-150,RB150,QGC001,RB 150	Aminopeptidase
	Firibastat (RB150) is a glutamyl aminopeptidase antagonist and an orally active brain penetrating prodrug of EC33. It is a first-in-class brain aminopeptidase A (APA) inhibitor with a Ki of 200 nM. Firibastat selectively...		Aminopeptidase
T8315	1-Cyclohexyl-3-dodecyl urea	CDU,N-Cyclohexyl-N-dodecyl urea,NCND	Epoxide Hydrolase
	1-Cyclohexyl-3-dodecyl urea (NCND) is a highly selective soluble epoxide hydrolase (sEH) inhibitor.		Epoxide Hydrolase
T26745	BAY 73-1449	BAY-73-1449,BAY73-1449	Others
	BAY-73-1449 is an antagonist of prostacyclin receptor.		Others
T3518	GSK269962A	GSK269962B,GSK 269962,GSK269962A HCl	ROCK , S6 Kinase
	GSK269962A (GSK269962A HCl) is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.		ROCK , S6 Kinase
T2547	Droxidopa	SM5688,DOPS,L-DOPS	Adrenergic Receptor
	Droxidopa (L-DOPS) is an orally available prodrug of norepinephrine that is used in the treatment of symptomatic orthostatic hypotension due to neurogenic causes of autonomic failure.		Adrenergic Receptor